Csaba Juhász, MD, PhD

Biography

Dr. Juhász is a  is a Professor of Pediatrics, Neurology, and Neurosurgery at Wayne State University School of Medicine. He is also a scientific member of the Karmanos Cancer Institute, Molecular Imaging Program. He previously was a faculty member of the Department of Neurology at the Semmelweis University in Budapest, Hungary, between 1994 and 1998, where he was involved in clinical work and research in epilepsy, clinical electrophysiology, stroke, and neurology intensive care. He completed a visiting research fellowship at the Department of Neurophysiology at the University of California, Los Angeles, in 1994-95. After completing a postdoctoral fellowship at the Positron Emission Tomography (PET) Center, Children's Hospital of Michigan (CHM) in Detroit, he became an assistant professor of Pediatrics and Neurology at WSU in 2001. He received his PhD from epilepsy imaging in 2002. He was promoted to associate professor with tenure in 2008 and to full professor in 2013 at Wayne State University.

Dr. Juhasz has been the principal investigator of several R01 grant projects funded by the National Institutes of Health (NIH) since 2003 to study progression of brain structural and functional abnormalities in Sturge-Weber syndrome and to explore the clinical use of tryptophan PET imaging in brain tumors. He is also a site PI of a multi-center NIH-funded U54 grant on Sturge-Weber syndrome. He published more than 200 scientific papers and dozens of book chapters. He also delivered >50 invited lectures at national and international meetings.

Research and Clinical Interests

• Structural and molecular imaging of patients with epilepsy, brain tumors, and developmental brain disorders, with a particular interest in the pathophysiology and progression of Sturge-Weber syndrome.

• PET imaging of brain metabolism, with a particular focus on tryptophan uptake and metabolism in brain tumors and epileptic foci.

• Multimodal imaging of brain damage and reorganization in the developing human brain.

Publications

Selected publications, from more than 200 published works:  

1. Jiang H, Guo Y, Cai H, Viola N, Shields AF, Muzik O, Juhász C. Automated radiosynthesis of 1-(2-[18F]fluoroethyl)-L-tryptophan ([18F]FETrp) for positron emission tomography (PET) imaging of cancer in humans. J Labelled Comp Radiopharm. 2023;66(7-8): 180-188.

2. Juhász C, Luat AF, Behen ME, Gjolaj N, Jeong JW, Chugani HT, Kumar A.  Deep venous remodeling in unilateral Sturge-Weber syndrome: Robust hemispheric differences and clinical correlates. Ped Neurol 2023;139:49-58.

3. O’Hara N, Lee MH, Juhász C, Asano E, Jeong JW. Diffusion tractography predicts propagated high-frequency activity during epileptic spasms. Epilepsia 2022;63:1787-1798.

4. Jeong JW, Lee MH, Kuroda N, Sakakura K, O’Hara N, Juhász C, Asano E. Multi-scale deep learning of clinically acquired multi-modal MRI improves the localization of seizure onset zone in children with drug-resistant epilepsy. IEEE J Biomed Health Inform. 2022;26(11):5529-39.

5. Stopa B, Crowley J, Kiser JW, Juhász C, Rogers CM, Witcher MR. Prostate specific membrane antigen for neuroimaging of central nervous system tumors: A systematic review. Mol Imaging 2022 Apr 15;2022:5358545.

6. John F, Michelhaugh SK, Barger GR, Mittal S, Juhász C. Depression and tryptophan metabolism in patients with primary brain tumors: Clinical and molecular imaging correlates. Brain Imaging Behav 2021;15(2):974-985.

7. Banerjee S, Dong M, Lee MH, O'Hara N, Juhász C, Asano E, Jeong JW. Deep relational reasoning for the prediction of language impairment and postoperative seizure outcome using preoperative DWI connectome data of children with focal epilepsy. IEEE Trans Med Imaging. 2021;40(3):793-804.

8. Juhász C, Mittal S. Molecular imaging of brain tumor-associated epilepsy. Diagnostics 2020; 10(12), 1049; https://doi.org/10.3390/diagnostics10121049

9. Bonomi R, John F, Patel S, Barger G, Robinette N, Amit-Yousif AJ, Dominello M, Juhász C. Multimodal neuroimaging of gliomatosis cerebri: a case series of four patients. Acta Radiol Open 2020 9(8):2058460120942789. doi: 10.1177/2058460120942789

10. Jeong JW, Lee MH, John F, Robinette NL, Amit-Yousif AJ, Barger GR, Mittal S, Juhász C. Feasibility of multimodal MRI-based deep learning prediction of high amino acid uptake regions and survival in patients with glioblastoma. Front Neurol 2019;10:1305. DOI: 10.3389/fneur.2019.01305

11. Day AM, McCulloch CE, Hammill AM, Juhász C, Lo WD, Pinto AL, Miles DK, Fisher BJ, Ball KL, Wilfong AA, Levin AV, Thau AJ, Comi A. Physical and family history variables associated with neurologic and cognitive development in Sturge-Weber syndrome. Pediatr Neurol 2019;96:30-36.

12. John F, Robinette NL, Amit-Yousif AJ, Bosnyák E, Barger GR, Shah KD, Mittal S, Juhász C. Multimodal imaging of nonenhancing glioblastoma regions. Mol Imaging. 2019 Jan-Dec;18:1536012119885222.

13. John F, Bosnyak E, Robinette NL, Amit-Yousif AJ, Barger GR, Shah KD, Michelhaugh SK, Klinger NV, Mittal S, Juhász C. Multimodal imaging-defined subregions in newly-diagnosed glioblastoma: Impact on overall survival. Neuro Oncol 2019;21:264-273.

14. Lukas RV, Juhász C, Wainwright DA, James CD, Kennedy E, Stupp R, Lesniak MS. Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod. J Neurooncol 2019;141:111-120.

15. Pilli VK, Jeong JW, Konka P, Kumar A, Chugani HT, Juhász C. Objective PET study of glucose metabolism asymmetries in children with epilepsy: Implications for normal brain development. Hum Brain Mapp 2019;40:53-64.

16. Govil-Dalela T, Kumar A, Behen ME, Chugani HT, Juhász C. Evolution of lobar abnormalities of cerebral glucose metabolism in 41 children with drug-resistant epilepsy. Epilepsia 2018;59:1307-1315.

17. Kim JA, Jeong JW, Behen ME, Pilli VK, Luat A, Chugani HT, Juhász C. Metabolic correlates of cognitive function in children with unilateral Sturge-Weber syndrome: Evidence for regional functional reorganization and crowding. Hum Brain Mapp. 2018;39:1596-1606.

18. Luat AF, Behen ME, Chugani HT, Juhász C. Cognitive and motor outcomes in children with unilateral Sturge-Weber syndrome: Effect of age of seizure onset and side of brain involvement. Epilepsy & Behavior 2018;80:202-207.

19. Sundaram S, Michelhaugh SK, Klinger NV, Kupsky WJ, Sood S, Chugani HT, Mittal S, Juhász C. GNAQ mutation in the venous vascular malformation and underlying brain tissue in Sturge-Weber syndrome. Neuropediatrics 2017;48:385-389.

20. Jeong JW, Asano E, Pilli V, Nakai Y, Chugani HT, Juhász C. Objective 3D surface evaluation of intracranial electrophysiologic correlates of cerebral glucose metabolic abnormalities in children with focal epilepsy. Hum Brain Mapp. 2017;38:3098-3112.

21. Pilli V, Behen ME, Hu J, Xuan Y, Janisse J, Chugani HT, Juhász C. Clinical and metabolic correlates of cerebral calcifications in Sturge-Weber syndrome. Dev Med Child Neurol 2017;59:952-958.

22. Bosnyák E, Michelhaugh SK, Klinger NV, Kamson DO, Barger GR, Mittal S, Juhász C. Prognostic molecular and imaging biomarkers in primary glioblastoma. Clin Nucl Med 2017;42(5):341-347

23. Pilli VK, Chugani HT, Juhász C. Enlargement of deep medullary veins during the early clinical course of Sturge-Weber syndrome. Neurology 2017;88(1):103-105.

24. Michelhaugh SK, Muzik O, Guastella AR, Klinger NV, Polin LA, Cai H, Xin Y, Mangner TJ, Zhang S, Juhász C, Mittal S. Assessment of tryptophan uptake and kinetics using 1-(2-[18F]fluoroethyl)-L-tryptophan and α-[11C]-methyl-L-tryptophan PET imaging in mice implanted with patient-derived brain tumor xenografts. J Nucl Med. 2017; 58:208-213.

25. Jeong JW, Asano E, Juhász C, Behen ME, Chugani HT. Postoperative axonal changes in the contralateral hemisphere in children with medically refractory epilepsy: A longitudinal diffusion tensor imaging connectome analysis. Hum Brain Mapp. 2016;37:3946-3956.

26. Kamson DO, Pilli VK, Asano E, Jeong JW, Sood S, Juhász C, Chugani HT. Cortical thickness asymmetries and surgical outcome in neocortical epilepsy. J Neurol Sci 2016;368:97-103.

27. Juhász C, Hu J, Xuan Y, Chugani HT. Imaging increased glutamate in children with Sturge-Weber syndrome: Association with epilepsy severity. Epilepsy Res. 2016;122:66-72.

28. Bosnyák E, Behen ME, Guy WC, Asano E, Juhász C. Predictors of cognitive functions in children with Sturge-Weber syndrome: A longitudinal study. Ped Neurol 2016;61:38-45.

29. Bosnyák E, Kamson DO, Robinette NL, Barger GR, Mittal S, Juhász C. Tryptophan PET predicts spatial and temporal patterns of post-treatment glioblastoma progression detected by contrast-enhanced MRI. J Neurooncol. 2016;126:317-25.

30. Bosnyák E, Kamson DO, Guastella A, Varadarajan K, Robinette NL, Kupsky WJ, Muzik O, Michelhaugh SK, Mittal S, Juhász C. Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas.  Neuro Oncol. 2015;17:1284-92.

31. Bosnyák E, Kamson DO, Behen ME, Barger GR, Mittal S, Juhász C. Imaging cerebral tryptophan metabolism in brain tumor-associated depression. EJNMMI Res. 2015;5:56. doi: 10.1186/s13550-015-0136-9.

32. Jeong JW, Lee J, Kamson DO, Chugani HT, Juhász C. Detection of hand and leg motor tract injury using novel diffusion tensor MRI tractography in children with central motor dysfunction. Magn Reson Imaging 2015;33:895-902.

33. Jeong JW, Tiwari VJ, Shin J, Chugani HT, Juhász C. Assessment of brain damage and plasticity in the visual system due to early occipital lesion: Comparison of FDG-PET with diffusion MRI tractography. J MRI 2015; 41:431-438.

34. Kamson DO, Juhász C, Chugani HT, Jeong JW. Novel diffusion tensor imaging technique reveals developmental streamline volume changes in the corticospinal tract associated with leg motor control. Brain Dev. 2015; 37:370-375.

35. Kamson DO, Lee TJ, Varadarajan K, Robinette NL, Muzik O, Chakraborty PK, Snyder M, Barger GR, Mittal S, Juhász C. Clinical significance of tryptophan metabolism in the nontumoral hemisphere in patients with malignant glioma. J Nucl Med. 2014;55:1605-1610.

36. Kamson DO, Mittal S, Robinette NL, Muzik O, Kupsky WJ, Barger GR, Juhász C. Increased tryptophan uptake on PET has strong independent prognostic value in patients with a previously treated high-grade glioma. Neuro Oncol. 2014;16:1373-1383.

37. Kamson DO, Mittal S, Buth A, Muzik O, Kupsky WJ, Robinette NL, Barger GR, Juhász C. Differentiation of glioblastomas from metastatic brain tumors by tryptophan uptake and kinetic analysis: a PET study with MRI comparison. Mol Imaging 2013;12(5):327-337.

38. Kamson DO, Juhász C, Buth A, Kupsky WJ, Barger GR, Chakraborty P, Muzik O, Mittal S. Tryptophan PET in pretreatment delineation of newly-diagnosed gliomas: MRI and histopathologic correlates. J Neurooncol 2013;112:121-32.

39. Jeong JW, Chugani HT, Juhász C. Localization of function-specific segments of the primary motor pathway in children with Sturge-Weber syndrome: A multimodal imaging analysis. J Magn Reson Imaging 2013;38(5):1152-61.

40. Jeong JW, Chugani HT, Behen ME, Guy W, Juhász C. Quantitative assessment of brain networks in children with Sturge-Weber syndrome using resting state functional MRI. J Child Neurol 2013;28(11):1448-55.

41. Juhász C, Chugani DC, Barger GR, Kupsky WJ, Chakraborty PK, Muzik O, Mittal S. Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: Correlation with tumor proliferative activity. Clin Nucl Med 2012;37:838-842. 

42. Juhász C, Nahleh Z, Zitron I, Chugani DC, Janabi MZ, Bandyopadhyay S, Ali-Fehmi R, Mangner TJ, Chakraborty PK, Mittal S, Muzik O. Tryptophan metabolism in breast cancers: Molecular imaging and immunohistochemistry studies. Nucl Med Biol 2012;39:926-932.

43. Alkonyi B, Barger GR, Mittal S, Muzik O, Chugani DC, Bahl G, Robinette NL, Kupsky WJ, Chakraborty PK, Juhász C. Accurate differentiation of recurrent gliomas from radiation injury by kinetic analysis of alpha-[11C]methyl-L-tryptophan PET. J Nucl Med 2012;53:1058-1064.

44. Alkonyi B, Mittal S, Zitron I, Chugani DC, Kupsky WJ, Muzik O, Chugani HT, Sood S, Juhász C. Increased tryptophan transport in epileptogenic dysembryoplastic neuroepithelial tumors. J Neurooncol 2012;107:365-372.

45. Alkonyi B, Miao Y, Wu J, Cai Z, Hu J, Chugani HT, Juhász C. A perfusion-metabolic mismatch in Sturge-Weber syndrome: A multimodality imaging study. Brain Dev 2012;34:553-562.

46. Behen ME, Juhász C, Wolfe-Christensen C, Guy W, Halverson S, Rothermel R, Janisse J, Chugani HT. Brain damage and IQ in unilateral Sturge-Weber syndrome: Support for a “fresh start” hypothesis. Epilepsy Behav 2011;22:352-357.

47. Wu J, Tarabishy B, Hu J, Miao Y, Cai Z, Xuan Y, Behen M, Ye Y, Shoskey R, Haacke EM, Juhász C. Cortical calcification in Sturge-Weber syndrome on MRI-SWI: Relation to brain perfusion status and seizure severity. J Magnetic Res Imaging 2011;34:791-798.

48. Chugani HT, Kumar A, Kupsky W, Asano E, Sood S, Juhász C. Clinical and histopathological correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy. Epilepsia 2011;52:1692-1698.

49. Alkonyi B, Chugani HT, Juhász C. Transient focal increase of interictal glucose metabolism in Sturge-Weber syndrome: implications for epileptogenesis. Epilepsia 2011;52:1265-1272.

50. Juhász C, Muzik O, Chugani DC, Chugani HT, Sood S, Chakraborty PK, Barger GR, Mittal S. Differential kinetics of a-[11C]methyl-L-tryptophan on PET in low-grade brain tumors. J Neurooncol 2011;102:409-415.

51. Kumar A, Juhász C, Asano E, Sood S, Muzik O, Chugani HT. Objective detection of epileptic foci by FDG PET in children undergoing epilepsy surgery. J Nucl Med 2010;51:1901-1907.

52. Asano E, Juhász C, Shah A, Sood S, Chugani HT. Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery. Brain 2009;132;1038-1047.

53. Batista CEA, Juhász C, Muzik O, Kupsky WJ, Barger G, Chugani HT, Chugani HT, Mittal S, Sood S, Chakraborty PK, Chugani DC. Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors. Mol Imaging Biol 2009;11:460-466.

54. Juhász C, Asano E, Shah A, Chugani DC, Muzik O, Sood S, Chugani HT. Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate? Epilepsia 2009;50:240-250.

55. Juhász C, Lai C, Behen ME, Muzik O, Helder EJ, Chugani DC, Chugani HT. White matter volume as a major predictor of cognitive function in Sturge-Weber syndrome. Arch Neurol 2007;64:1169-1174.

56. Juhász C, Haacke M, Hu J, Xuan Y, Makki M, Behen ME, Maqbool M, Muzik O, Chugani DC, Chugani HT. Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. AJNR Am J Neuroradiol 2007; 28:900-906.

57. Juhász C, Batista EA, Chugani DC, Muzik O, Chugani HT. Evolution of cortical metabolic abnormalities and their clinical correlates in Sturge-Weber syndrome. Eur J Paediatr Neurol 2007;11:277-84.

58. Juhász C, Chugani DC, Padhye UN, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK, Sood S, Chugani HT. Evaluation with alpha-[11C]methyl-L-tryptophan PET for reoperation after failed epilepsy surgery. Epilepsia 2004;45:124-130.

59. Pfund Z, Kagawa K, Juhász C, Shen C, Lee JS, Chugani DC, Muzik O, Chugani HT. Quantitative analysis of gray and white matter volumes and glucose metabolism in Sturge-Weber syndrome. J Child Neurol 2003;18:119-126.

60. Juhász C, Chugani DC, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK, Sood S, Chugani HT. Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology 2003;60:960-968.

61. Juhász C, Muzik O, Chugani DC, Chengang Shen, Janisse J, Chugani HT. Prolonged vigabatrin treatment modifies developmental changes of GABAA receptor binding in young children with epilepsy. Epilepsia 2001;42:1320-1326.

62. Juhász C, Behen ME, Muzik O, Chugani DC, Chugani HT.  Bilateral prefrontal and temporal neocortical hypometabolism in children with epilepsy and aggression. Epilepsia 2001;42:991-1001.

63. Lee JS, Asano E, Muzik O, Chugani DC, Juhász C, Pfund Z, Philip S, Behen ME, Chugani HT. Sturge-Weber syndrome: correlation between clinical course and FDG PET findings. Neurology 2001;57: 2001; 57:189-195.

64. Juhász C, Chugani DC, Muzik O, Shah A, Shah J, Watson C, Canady A, Chugani HT. Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery outcome. Neurology 2001;56:1650-1658.

65. Chugani DC, Muzik O, Juhász C, Janisse JJ, Ager J, Chugani HT. Postnatal maturation of human GABAA receptors measured with positron emission tomography. Ann Neurol 2001;49:618-626.

66. Muzik O, Chugani DC, Juhász C, Shen C, Chugani HT. Statistical parametric mapping: assessment of application in children. Neuroimage 2000;12:538-549.

67. Juhász C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT. Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology 2000;55:825-834.

68. Juhász C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT. Is epileptogenic cortex truly hypometabolic on interictal positron emission tomography? Ann Neurol 2000;48:88-96.

69. Juhász C, Nagy F, Watson C, da Silva EA, Muzik O, Chugani DC, Shah J, Chugani HT. Glucose and [11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy. Neurology 1999;53:2037-2045.

70. Juhász C, Nagy F, Muzik O, Watson C, Shah J, Chugani HT. 11C-Flumazenil PET in patients with epilepsy with dual pathology. Epilepsia 1999;40:566-574.