Michael Behen, PhD

Biography

Michael E. Behen, Ph.D., is a clinical psychologist/neuroscientist in the Translational Imaging Center at Children's Hospital of Michigan. Dr. Behen's research and clinical interests include the neurocognitive, behavioral, and imaging correlates of early social deprivation, Tourette Syndrome, and developmental and psychiatric disorders. His work is currently funded by the National Institute of Mental Health. 

Research and Clinical Interests

• Dr. Behen's research and clinical interests include the neurocognitive, behavioral, and imaging correlates of early social deprivation, Tourette Syndrome, and developmental disorders. 

Publications

• Juhász C, Luat AF, Behen ME, Gjolaj N, Jeong JW, Chugani HT, Kumar A. Deep Venous Remodeling in Unilateral Sturge-Weber Syndrome: Robust Hemispheric Differences and Clinical Correlates. Pediatr Neurol. 2023;139:49-58. doi: 10.1016/j.pediatrneurol.2022.11.011. PMID: 36521316.

• Jeong JW, Banerjee S, Lee MH, O'Hara N, Behen M, Juhász C, Dong M. Deep reasoning neural network analysis to predict language deficits from psychometry-driven DWI connectome of young children with persistent language concerns. Hum Brain Mapp. 2021;42(10):3326-3338. doi: 10.1002/hbm.25437. PMID: 33949048.

• Lee MH, O'Hara NB, Behen ME, Jeong JW. Altered efficiency of white matter connections for language function in children with language disorder. Brain Lang. 2020;203:104743. doi: 10.1016/j.bandl.2020.104743. PMID: 32004807.

• Kumar A, Juhász C, Luat A, Govil-Dalela T, Behen ME, Hicks MA, Chugani HT. Evolution of Brain Glucose Metabolic Abnormalities in Children With Epilepsy and SCN1A Gene Variants. J Child Neurol. 2018;33(13):832-836. doi: 10.1177/0883073818796373. PMID: 30182801. 

• Govil-Dalela T, Kumar A, Behen ME, Chugani HT, Juhász C. Evolution of lobar abnormalities of cerebral glucose metabolism in 41 children with drug-resistant epilepsy. Epilepsia. 2018;59(7):1307-1315. doi: 10.1111/epi.14404. PMID: 29786852.

• John F, Maqbool M, Jeong JW, Agarwal R, Behen ME, Juhász C. Deep cerebral vein expansion with metabolic and neurocognitive recovery in Sturge-Weber syndrome. Ann Clin Transl Neurol. 2018 Mar 12;5(4):502-506. doi: 10.1002/acn3.546. PMID: 29687028.

• Luat AF, Behen ME, Chugani HT, Juhász C. Cognitive and motor outcomes in children with unilateral Sturge-Weber syndrome: Effect of age at seizure onset and side of brain involvement. Epilepsy Behav. 2018;80:202-207. doi: 10.1016/j.yebeh.2018.01.012. PMID: 29414553.

• Kim JA, Jeong JW, Behen ME, Pilli VK, Luat A, Chugani HT, Juhász C. Metabolic correlates of cognitive function in children with unilateral Sturge-Weber syndrome: Evidence for regional functional reorganization and crowding. Hum Brain Mapp. 2018;39(4):1596-1606. doi: 10.1002/hbm.23937. PMID: 29274110.

• Pilli VK, Behen ME, Hu J, Xuan Y, Janisse J, Chugani HT, Juhász C. Clinical and metabolic correlates of cerebral calcifications in Sturge-Weber syndrome. Dev Med Child Neurol. 2017;59(9):952-958. doi: 10.1111/dmcn.13433. PMID: 28397986.

• Bosnyák E, Behen ME, Guy WC, Asano E, Chugani HT, Juhász C. Predictors of Cognitive Functions in Children With Sturge-Weber Syndrome: A Longitudinal Study. Pediatr Neurol. 2016;61:38-45. doi: 10.1016/j.pediatrneurol.2016.05.012. PMID: 27353695.

• Jeong JW, Asano E, Juhász C, Behen ME, Chugani HT. Postoperative axonal changes in the contralateral hemisphere in children with medically refractory epilepsy: A longitudinal diffusion tensor imaging connectome analysis. Hum Brain Mapp. 2016;37(11):3946-3956. doi: 10.1002/hbm.23287. PMID: 27312605.

• Jeong JW, Sundaram S, Behen ME, Chugani HT. Relationship between genotype and arcuate fasciculus morphology in six young children with global developmental delay: Preliminary DTI stuy. J Magn Reson Imaging. 2016;44(6):1504-1512. doi: 10.1002/jmri.25306. PMID: 27251476.

• Chugani DC, Chugani HT, Wiznitzer M, Parikh S, Evans PA, Hansen RL, Nass R, Janisse JJ, Dixon-Thomas P, Behen M, Rothermel R, Parker JS, Kumar A, Muzik O, Edwards DJ, Hirtz D; Autism Center of Excellence Network. Efficacy of Low-Dose Buspirone for Restricted and Repetitive Behavior in Young Children with Autism Spectrum Disorder: A Randomized Trial. J Pediatr. 2016;170:45-53.e1-4. doi: 10.1016/j.jpeds.2015.11.033. PMID: 26746121. 

• Dhakar MB, Ilyas M, Jeong JW, Behen ME, Chugani HT. Frontal Aslant Tract Abnormality on Diffusion Tensor Imaging in an Aphasic Patient With 49, XXXXY Syndrome. Pediatr Neurol. 2016;55:64-7. doi: 10.1016/j.pediatrneurol.2015.10.020. PMID: 26706051.

• Bosnyák E, Kamson DO, Behen ME, Barger GR, Mittal S, Juhász C. Imaging cerebral tryptophan metabolism in brain tumor-associated depression. EJNMMI Res. 2015;5(1):56. doi: 10.1186/s13550-015-0136-9. PMID: 26475140.

• Jeong JW, Tiwari VN, Behen ME, Chugani HT, Chugani DC. In vivo detection of reduced Purkinje cell fibers with diffusion MRI tractography in children with autistic spectrum disorders. Front Hum Neurosci. 2014;8:110. doi: 10.3389/fnhum.2014.00110. PMID: 24592234.

• Kamson DO, Juhász C, Shin J, Behen ME, Guy WC, Chugani HT, Jeong JW. Patterns of structural reorganization of the corticospinal tract in children with Sturge-Weber syndrome. Pediatr Neurol. 2014;50(4):337-42. doi: 10.1016/j.pediatrneurol.2013.12.012. PMID: 24507695.

• Kumar A, Behen ME, Singsoonsud P, Veenstra AL, Wolfe-Christensen C, Helder E, Chugani HT. Microstructural abnormalities in language and limbic pathways in orphanage-reared children: a diffusion tensor imaging study. J Child Neurol. 2014;29(3):318-25. doi: 10.1177/0883073812474098. PMID: 23358628.

• Jeong JW, Chugani HT, Behen ME, Guy W, Juhász C. Quantitative Assessment of Brain Networks in Children With Sturge-Weber Syndrome Using Resting State Functional Magnetic Resonance Imaging (MRI). J Child Neurol. 2013;28(11):1448-1455. doi: 10.1177/0883073812469296. PMID: 23271758.

• Larsen TL, Helder EJ, Behen ME. Neurocognitive and behavioral correlates of non-right-handedness in internationally adopted children. J Clin Exp Neuropsychol. 2012;34(9):999-1007. doi: 10.1080/13803395.2012.716395. PMID: 22934627.

• Jeong JW, Chugani DC, Behen ME, Tiwari VN, Chugani HT. Altered white matter structure of the dentatorubrothalamic pathway in children with autistic spectrum disorders. Cerebellum. 2012;11(4):957-71. doi: 10.1007/s12311-012-0369-3. PMID: 22477362.

• Shandal V, Veenstra AL, Behen M, Sundaram S, Chugani H. Long-term outcome in children with intractable epilepsy showing bilateral diffuse cortical glucose hypometabolism pattern on positron emission tomography. J Child Neurol. 2012;27(1):39-45. doi: 10.1177/0883073811416363. PMID: 21940690.

• Behen ME, Juhász C, Wolfe-Christensen C, Guy W, Halverson S, Rothermel R, Janisse J, Chugani HT. Brain damage and IQ in unilateral Sturge-Weber syndrome: support for a "fresh start" hypothesis. Epilepsy Behav. 2011;22(2):352-7. doi: 10.1016/j.yebeh.2011.07.010. PMID: 21852199.

• Gopal SP, Tiwari VN, Veenstra AL, Kumar A, Behen M, Chugani HT, Sundaram SK. Sensitive diffusion tensor imaging quantification method to identify language pathway abnormalities in children with developmental delay. J Pediatr. 2012;160(1):147-51. doi: 10.1016/j.jpeds.2011.06.036. PMID: 21839473.

• Tiwari VN, Jeong JW, Wilson BJ, Behen ME, Chugani HT, Sundaram SK. Relationship between aberrant brain connectivity and clinical features in Angelman Syndrome: a new method using tract based spatial statistics of DTI color-coded orientation maps. Neuroimage. 2012;59(1):349-55. doi: 10.1016/j.neuroimage.2011.07.067. PMID: 21827860.

• Wu J, Tarabishy B, Hu J, Miao Y, Cai Z, Xuan Y, Behen M, Li M, Ye Y, Shoskey R, Haacke EM, Juhász C. Cortical calcification in Sturge-Weber Syndrome on MRI-SWI: relation to brain perfusion status and seizure severity. J Magn Reson Imaging. 2011;34(4):791-8. doi: 10.1002/jmri.22687. PMID: 21769978.

• Shandal V, Sundaram SK, Chugani DC, Kumar A, Behen ME, Chugani HT. Abnormal brain protein synthesis in language areas of children with pervasive developmental disorder: a L-[1-11C]-leucine PET study. J Child Neurol. 2011;26(11):1347-54. doi: 10.1177/0883073811405200. PMID: 21636781.

• Alkonyi B, Chugani HT, Karia S, Behen ME, Juhász C. Clinical outcomes in bilateral Sturge-Weber syndrome. Pediatr Neurol. 2011;44(6):443-9. doi: 10.1016/j.pediatrneurol.2011.01.005. PMID: 21555056.

• Goradia D, Chugani HT, Govindan RM, Behen M, Juhász C, Sood S. Reorganization of the right arcuate fasciculus following left arcuate fasciculus resection in children with intractable epilepsy. J Child Neurol. 2011;26(10):1246-51. doi: 10.1177/0883073811402689. PMID: 21551371.

• Sundaram SK, Huq AM, Sun Z, Yu W, Bennett L, Wilson BJ, Behen ME, Chugani HT. Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. Ann Neurol. 2011;69(5):901-4. doi: 10.1002/ana.22398. PMID: 21520241