Biography

Professor of Pediatrics and Radiology at Wayne State University, Detroit, Michigan. Originates from Vienna, Austria and obtained a PhD in Physics from the Technical University of Vienna in collaboration with the KFA Julich (NW, Germany). Prior to his appointment at Wayne State University, conducted post-doctoral research at the University of Michigan in Ann Arbor. Expertise as PET physicist, specifically in the kinetic analysis and quantification of PET imaging data as well as in the development of image analysis software for integrative analysis of pediatric imaging data.

Dr. Muzik is a medical physicist who was recruited from the University of Michigan in 1993 to assume the role of a senior physicist in the newly opened Children's Hospital of Michigan PET Center. Since then he established himself as an expert in the kinetic analysis of PET data as well as through his work in the development of image analysis software for integrative analysis of pediatric imaging data. Dr. Muzik is also in charge of the microPET/CT core facility at the WSU Medical School.

Dr. Muzik's research interests include the quantitative analysis of oxidative metabolism in Brown Adipose Tissue (BAT) with the objective to establish the relationship between BAT thermogenesis and uptake of FDG, a widely used (but indirect) measure of brown fat metabolism. In addition, Dr. Muzik’s research includes the development of methods that allow quantitative integration of multimodality neuroimaging data obtained from PET, MR and fMRI data.

Graduate:

University of Vienna, Austria, PhD in 1989

Post Doctoral:

University of Michigan, Department of Radiology, 1990-1993 

Prior Appointments:

Staff PET physicist, Nuclear Research Center Julich, Nordrhein-Westfalen, Germany, 1989-1990

Research and Clinical Interests

Kinetic modeling, functional PET imaging in the brain and myocardium, quantitative assessment of Brown Fat metabolism, quantification of myocardial perfusion, clinical applications of advanced multimodality imaging techniques for pre-surgical evaluation of epilepsy patients, microPET imaging in newborns and in preclinical models.

Publications (25 most recent publications from a total of 214)

1. Muzik O, Diwadkar VA. Depth and hierarchies in the predictive brain: Fromreaction to action. Wiley Interdiscip Rev Cogn Sci. 2023 Jul 30:e1664. doi:10.1002/wcs.1664. Epub ahead of print. PMID: 37518831.

2. Shiyam Sundar LK, Lassen ML, Gutschmayer S, Ferrara D, Calabrò A, Yu J, KlugeK, Wang Y, Nardo L, Hasbak P, Kjaer A, Abdelhafez YG, Wang G, Cherry SR, SpencerBA, Badawi RD, Beyer T, Muzik O. Fully Automated, Fast Motion Correction of Dynamic Whole-Body and Total-Body PET/CT Imaging Studies. J Nucl Med. 2023 Jul;64(7):1145-1153. doi: 10.2967/jnumed.122.265362. Epub 2023 Jun 8. PMID 37290795.

3. Jiang H, Guo Y, Cai H, Viola N, Shields AF, Muzik O, Juhasz C. Automated radiosynthesis of 1-(2-[¹⁸ F]fluoroethyl)-L-tryptophan ([¹⁸ F]FETrp) for positron emission tomography (PET) imaging of cancer in humans. J Labelled Comp Radiopharm. 2023 Jun;66(7-8):180-188. doi: 10.1002/jlcr.4027. Epub 2023 May 11. PMID: 37118900; PMCID: PMC10330273.

4. Peterson AB, Wang C, Wong KK, Frey KA, Muzik O, Schipper MJ, Dewaraja YK. 177Lu-DOTATATE Theranostics: Predicting Renal Dosimetry From Pretherapy 68Ga-DOTATATE PET and Clinical Biomarkers. Clin Nucl Med. 2023 May 1;48(5):393-399. doi: 10.1097/RLU.0000000000004599. Epub 2023 Feb 8. PMID: 37010563; PMCID: PMC10353839.

5. Kertész H, Traub-Weidinger T, Cal-Gonzalez J, Rausch I, Muzik O, Shyiam Sundar LK, Beyer T. Feasibility of dose reduction for [18F]FDG-PET/MR imaging of patients with non-lesional epilepsy. Nuklearmedizin. 2023 Jun;62(3):200-213. English. doi: 10.1055/a-2015-7785. Epub 2023 Feb 20. PMID: 36807894.

6. Shiyam Sundar LK, Yu J, Muzik O, Kulterer OC, Fueger B, Kifjak D, Nakuz T, Shin HM, Sima AK, Kitzmantl D, Badawi RD, Nardo L, Cherry SR, Spencer BA, Hacker M, Beyer T. Fully Automated, Semantic Segmentation of Whole-Body ¹⁸F-FDG PET/CT Images Based on Data-Centric Artificial Intelligence. J Nucl Med. 2022 Dec;63(12):1941-1948. doi: 10.2967/jnumed.122.264063. Epub 2022 Jun 30. PMID: 35772962; PMCID: PMC9730926.

7. Muzik O, Baajour S, Chowdury A, Diwadkar VA. Effective connectivity of brain networks controlling human thermoregulation. Brain Struct Funct. 2022 Jan;227(1):299-312. doi: 10.1007/s00429-021-02401-w. Epub 2021 Oct 4. PMID: 34605996.

8. Shiyam Sundar LK, Iommi D, Muzik O, Chalampalakis Z, Klebermass EM, Hienert M, Rischka L, Lanzenberger R, Hahn A, Pataraia E, Traub-Weidinger T, Hummel J, Beyer T. Conditional Generative Adversarial Networks Aided Motion Correction of Dynamic ¹⁸F-FDG PET Brain Studies. J Nucl Med. 2021 Jun 1;62(6):871-879. doi: 10.2967/jnumed.120.248856. Epub 2020 Nov 27. PMID: 33246982; PMCID: PMC8729870.

9. Shiyam Sundar LK, Muzik O, Buvat I, Bidaut L, Beyer T. Potentials and caveats of AI in hybrid imaging. Methods. 2021 Apr;188:4-19. doi: 10.1016/j.ymeth.2020.10.004. Epub 2020 Oct 15. PMID: 33068741.

10. Muzik O, Baajour S, Bressler S, Diwadkar VA. Directional Interactions Between Constituents of the Human Large-Scale Thermoregulatory Network. Brain Topogr. 2020 Jul;33(4):489-503. doi: 10.1007/s10548-020-00778-1. Epub 2020 Jun 4. PMID: 32500213.

11. Shiyam Sundar LK, Baajour S, Beyer T, Lanzenberger R, Traub-Weidinger T, Rausch I, Pataraia E, Hahn A, Rischka L, Hienert M, Klebermass EM, Muzik O. Fully Integrated PET/MR Imaging for the Assessment of the Relationship Between Functional Connectivity and Glucose Metabolic Rate. Front Neurosci. 2020 Mar 25;14:252. doi: 10.3389/fnins.2020.00252. PMID: 32269510; PMCID: PMC7111429.

12. Traub-Weidinger T, Muzik O, Sundar LKS, Aull-Watschinger S, Beyer T, Hacker M, Hahn A, Kasprian G, Klebermass EM, Lanzenberger R, Mitterhauser M, Pilz M,Rausch I, Rischka L, Wadsak W, Pataraia E. Utility of Absolute Quantification in Non-lesional Extratemporal Lobe Epilepsy Using FDG PET/MR Imaging. Front Neurol. 2020 Jan 31;11:54. doi: 10.3389/fneur.2020.00054. PMID: 32082251; PMCID: PMC7005011.

13. John F, Muzik O, Mittal S, Juhász C. Fluorine-18-Labeled PET Radiotracers for Imaging Tryptophan Uptake and Metabolism: a Systematic Review. Mol Imaging Biol. 2020 Aug;22(4):805-819. doi: 10.1007/s11307-019-01430-6. PMID: 31512038; PMCID: PMC7064410.

14. Muzik O, Diwadkar VA. Hierarchical control systems for the regulation of physiological homeostasis and affect: Can their interactions modulate mood and anhedonia? Neurosci Biobehav Rev. 2019 Oct;105:251-261. doi: 10.1016/j.neubiorev.2019.08.015. Epub 2019 Aug 20. PMID: 31442518.

15. Shiyam Sundar LK, Muzik O, Rischka L, Hahn A, Lanzenberger R, Hienert M, Klebermass EM, Bauer M, Rausch I, Pataraia E, Traub-Weidinger T, Beyer T. Promise of Fully Integrated PET/MRI: Noninvasive Clinical Quantification of Cerebral Glucose Metabolism. J Nucl Med. 2020 Feb;61(2):276-284. doi: 10.2967/jnumed.119.229567. Epub 2019 Aug 2. PMID: 31375567; PMCID: PMC8801961.

16. Bonomi R, Popov V, Laws MT, Gelovani D, Majhi A, Shavrin A, Lu X, Muzik O, Turkman N, Liu R, Mangner T, Gelovani JG. Molecular Imaging of Sirtuin1 Expression-Activity in Rat Brain Using Positron-Emission Tomography-Magnetic-Resonance Imaging with [¹⁸F]-2-Fluorobenzoylaminohexanoicanilide. J Med Chem. 2018 Aug 23;61(16):7116-7130. doi: 10.1021/acs.jmedchem.8b00253. Epub 2018 Aug 13. PMID: 30052441; PMCID: PMC6130205.

17. Sundar LK, Muzik O, Rischka L, Hahn A, Rausch I, Lanzenberger R, Hienert M, Klebermass EM, Füchsel FG, Hacker M, Pilz M, Pataraia E, Traub-Weidinger T, Beyer T. Towards quantitative [18F]FDG-PET/MRI of the brain: Automated MR-driven calculation of an image-derived input function for the non-invasive determination of cerebral glucose metabolic rates. J Cereb Blood Flow Metab. 2019 Aug;39(8):1516-1530. doi: 10.1177/0271678X18776820. Epub 2018 May 23. PMID: 29790820; PMCID: PMC6681439.

18. Mohammadi-Nejad AR, Mahmoudzadeh M, Hassanpour MS, Wallois F, Muzik O, Papadelis C, Hansen A, Soltanian-Zadeh H, Gelovani J, Nasiriavanaki M. Neonatal brain resting-state functional connectivity imaging modalities. Photoacoustics. 2018 Feb 2;10:1-19. doi: 10.1016/j.pacs.2018.01.003. PMID: 29511627; PMCID: PMC5832677.

19. Muzik O, Reilly KT, Diwadkar VA. "Brain over body"-A study on the willful regulation of autonomic function during cold exposure. Neuroimage. 2018 May 15;172:632-641. doi: 10.1016/j.neuroimage.2018.01.067. Epub 2018 Feb 10. PMID: 29438845.

20. Peng F, Xie F, Muzik O. Alteration of Copper Fluxes in Brain Aging: A Longitudinal Study in Rodent Using ⁶⁴CuCl₂-PET/CT. Aging Dis. 2018 Feb 1;9(1):109-118. doi: 10.14336/AD.2017.1025. PMID: 29392086; PMCID: PMC5772849.

21. Muzik O, Diwadkar VA. Regulation of Brown Adipose Tissue Activity by Interoceptive CNS Pathways: The interaction between Brain and Periphery. Front Neurosci. 2017 Nov 16;11:640. doi: 10.3389/fnins.2017.00640. PMID: 29200996; PMCID: PMC5696740.

22. Lassen ML, Muzik O, Beyer T, Hacker M, Ladefoged CN, Cal-González J, Wadsak W, Rausch I, Langer O, Bauer M. Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System. Front Neurosci. 2017 Jul 17;11:396. doi: 10.3389/fnins.2017.00396. PMID: 28769742; PMCID: PMC5511842.

23. Muzik O, Burghardt P, Yi Z, Kumar A, Seyoum B. Successful metformin treatment of insulin resistance is associated with down-regulation of the kynurenine pathway. Biochem Biophys Res Commun. 2017 Jun 17;488(1):29-32. doi: 10.1016/j.bbrc.2017.04.155. Epub 2017 May 4. PMID: 28478038; PMCID: PMC5554450.

24. Xie F, Xi Y, Pascual JM, Muzik O, Peng F. Age-dependent changes of cerebral copper metabolism in Atp7b ^-/- knockout mouse model of Wilson's disease by [⁶⁴Cu]CuCl₂-PET/CT. Metab Brain Dis. 2017 Jun;32(3):717-726. doi: 10.1007/s11011-017-9956-9. Epub 2017 Jan 27. PMID: 28130615; PMCID: PMC5573586.

25. Muzik O, Mangner TJ, Leonard WR, Kumar A, Granneman JG. Sympathetic Innervation of Cold-Activated Brown and White Fat in Lean Young Adults. J Nucl Med. 2017 May;58(5):799-806. doi: 10.2967/jnumed.116.180992. Epub 2016 Oct 27. PMID: 27789721; PMCID: PMC5414500.